Our research is featured on the cover of Journal of Virology!

An image accompanying our recent publication with the Zhang lab was selected for the September 2018 cover of Journal of Virology!

Zhou, with the help of Mike Calderon from Simon Watkins' lab, took this image on the STED3X microscope. Truncation of cleavage and polyadenylation specificity factor 6 at amino acid 358 (CPSF6-358) leads to cytoplasmic localization of the protein and potent inhibition of HIV-1 infection, which is dependent on binding to viral capsid. Apparent higher-order complexes of CPSF6-358–GFP (green) form when expressed in HeLa cells and after infection with wild-type HIV-1 containing viral integrase fused to mRuby3 (red). Microtubules are stained with SiR-tubulin (white), and nuclei are stained with Hoechst (blue). (© 2018 American Society for Microbiology. All Rights Reserved.)