Our collaborators Alex Guseman and Angela Gronenborn proposed that lectins in the Oscillatoria agardhii agglutinin (OAA) family could bind SARS-CoV-2 S protein and inhibit infection. Using S pseudotyped lentivirus, Chandra showed that one OAA lectin, BOA, could potently inhibit infection (2 nM EC50). This was confirmed in collaboration with the Duprex lab and David Martinez […]
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