The Ambrose Lab

The Ambrose laboratory studies HIV pathogenesis and therapeutics. We use both molecular and cellular retrovirology methods as well as in vivo models to address important questions about HIV infection and drugs for prevention and treatment. We also do coronavirus research.
Our Research Who We Are

About

The Ambrose Lab in the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine studies antiretroviral therapeutics used for HIV-1 prevention and suppression, including understanding virus-host protein interactions that can be exploited as novel drug targets, and the impact of drug resistance on HIV-1 transmission, prevention, and treatment. Recently our studies have expanded to SARS-CoV-2.
Molecular biology
Cellular virology
Animal models
Imaging
Genetics

Projects

The lab conducts multiple molecular and cellular virology projects as well as uses models to research important aspects of HIV infection, disease, and treatment. We also have some SARS-CoV-2 projects. Check it out!

Ambrose Lab News

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Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb coinfection
Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis, is the most common infectious disease that causes death, responsible for 1.25…
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Hannah shows role of E protein in SARS-CoV-2 infection
Hannah's preprint is out now! Check it out here. We designed a reverse genetics platform for production of SARS-CoV-2 based…
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Zac’s paper published in mBio!
HIV encodes a protein that forms a conical shell, called a capsid, that surrounds its genome. The capsid has been…
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New HIV Infections in 2023
AIDS Related Deaths in 2023
People Living with HIV in 2023

Our Team

Meet the researchers of the Ambrose Lab!
Zandrea Ambrose, PhD
Zandrea Ambrose, PhD

Principal Investigator

Hardcore retrovirologist

Chandra Nath Roy, PhD
Chandra Nath Roy, PhD

Staff Scientist

Humanized mouse expert

    Hannah Fischer, PhD
    Hannah Fischer, PhD

    Postdoctoral Scholar

    Resident reverse geneticist

      Priya Shanmugapriya, PhD
      Priya Shanmugapriya, PhD

      Postdoctoral Associate

      Cell biology scholar

        Zac Ingram, MS
        Zac Ingram, MS

        PhD Student

        Microscope maestro

          Ella Begovic
          Ella Begovic

          MS Student

          Molecular maven

            Ashley Gnanasekaran
            Ashley Gnanasekaran

            Undergrad Student

            Genotype guru

              Lilith Scheele
              Lilith Scheele

              MIDS Student

              Newest team member

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