A collaboration with the Yamashita Lab was just published in Journal of Virology

Our friend and collaborator, Dr. Masa Yamashita, identified a transmitted/founder HIV-1 strain (CH040) that is resistant to a small molecule inhibitor of HIV-1 capsid (PF74). His lab identified mutations in this viral isolate that alter capsid stability and prevent an innate immune response. In our lab, Doug Fischer performed the HIV-1 capsid permeabilization assay for the study that showed that the capsid from this unique clinical HIV-1 isolate was more stable than common laboratory strains. Doug's data correspond to a separate assay performed by Dr. Greg Melikyan's lab.